Pharmacokinetics of Diclofenac and Hydroxypropyl‐β‐Cyclodextrin (HPβCD) Following Administration of Injectable HPβCD‐Diclofenac in Subjects With Mild to Moderate Renal Insufficiency or Mild Hepatic Impairment

Given their established analgesic properties, nonsteroidal anti‐inflammatory drugs (NSAIDs) represent an important postoperative pain management option. This study investigated: (1) the effects of mild or moderate renal insufficiency and mild hepatic impairment on the pharmacokinetics (PK) of diclof...

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Detalhes bibliográficos
Publicado no:Clin Pharmacol Drug Dev
Main Authors: Hamilton, Douglas A., Ernst, Cynthia C., Kramer, William G., Madden, Donna, Lang, Eric, Liao, Edward, Lacouture, Peter G., Ramaiya, Atulkumar, Carr, Daniel B.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5814843/
https://ncbi.nlm.nih.gov/pubmed/29197175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpdd.417
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