Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires ecto-5'-nucleotidase-mediated conversion of adenine nucleotides.

We and others have shown that an increased extracellular concentration of adenosine mediates the antiinflammatory effects of methotrexate and sulfasalazine both in vitro and in vivo, but the mechanism by which these drugs increase extracellular adenosine remains unclear. The results of the experimen...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Clin Invest
Egile Nagusiak: Morabito, L, Montesinos, M C, Schreibman, D M, Balter, L, Thompson, L F, Resta, R, Carlin, G, Huie, M A, Cronstein, B N
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 1998
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508567/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9435300/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI1554
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