Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires ecto-5'-nucleotidase-mediated conversion of adenine nucleotides.

We and others have shown that an increased extracellular concentration of adenosine mediates the antiinflammatory effects of methotrexate and sulfasalazine both in vitro and in vivo, but the mechanism by which these drugs increase extracellular adenosine remains unclear. The results of the experimen...

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Hlavní autoři: Morabito, L, Montesinos, M C, Schreibman, D M, Balter, L, Thompson, L F, Resta, R, Carlin, G, Huie, M A, Cronstein, B N
Médium: Artigo
Jazyk:Inglês
Vydáno: 1998
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC508567/
https://ncbi.nlm.nih.gov/pubmed/9435300
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