Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires ecto-5'-nucleotidase-mediated conversion of adenine nucleotides.

We and others have shown that an increased extracellular concentration of adenosine mediates the antiinflammatory effects of methotrexate and sulfasalazine both in vitro and in vivo, but the mechanism by which these drugs increase extracellular adenosine remains unclear. The results of the experimen...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Morabito, L, Montesinos, M C, Schreibman, D M, Balter, L, Thompson, L F, Resta, R, Carlin, G, Huie, M A, Cronstein, B N
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1998
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508567/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9435300/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI1554
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