Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires ecto-5'-nucleotidase-mediated conversion of adenine nucleotides.

We and others have shown that an increased extracellular concentration of adenosine mediates the antiinflammatory effects of methotrexate and sulfasalazine both in vitro and in vivo, but the mechanism by which these drugs increase extracellular adenosine remains unclear. The results of the experimen...

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Bibliografiska uppgifter
Huvudupphovsmän: Morabito, L, Montesinos, M C, Schreibman, D M, Balter, L, Thompson, L F, Resta, R, Carlin, G, Huie, M A, Cronstein, B N
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1998
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC508567/
https://ncbi.nlm.nih.gov/pubmed/9435300
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