Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires ecto-5'-nucleotidase-mediated conversion of adenine nucleotides.

We and others have shown that an increased extracellular concentration of adenosine mediates the antiinflammatory effects of methotrexate and sulfasalazine both in vitro and in vivo, but the mechanism by which these drugs increase extracellular adenosine remains unclear. The results of the experimen...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Morabito, L, Montesinos, M C, Schreibman, D M, Balter, L, Thompson, L F, Resta, R, Carlin, G, Huie, M A, Cronstein, B N
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1998
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508567/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9435300/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI1554
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