Low-dose IL-2 selectively activates subsets of CD4(+) Tregs and NK cells

CD4(+) regulatory T cells (CD4Tregs) play a critical role in the maintenance of immune tolerance and prevention of chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation. IL-2 supports the proliferation and survival of CD4Tregs and previous studies have dem...

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Détails bibliographiques
Publié dans:JCI Insight
Auteurs principaux: Hirakawa, Masahiro, Matos, Tiago, Liu, Hongye, Koreth, John, Kim, Haesook T., Paul, Nicole E., Murase, Kazuyuki, Whangbo, Jennifer, Alho, Ana C., Nikiforow, Sarah, Cutler, Corey, Ho, Vincent T., Armand, Philippe, Alyea, Edwin P., Antin, Joseph H., Blazar, Bruce R., Lacerda, Joao F., Soiffer, Robert J., Ritz, Jerome
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5085610/
https://ncbi.nlm.nih.gov/pubmed/27812545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.89278
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