Low-dose IL-2 selectively activates subsets of CD4(+) Tregs and NK cells

CD4(+) regulatory T cells (CD4Tregs) play a critical role in the maintenance of immune tolerance and prevention of chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation. IL-2 supports the proliferation and survival of CD4Tregs and previous studies have dem...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Hirakawa, Masahiro, Matos, Tiago, Liu, Hongye, Koreth, John, Kim, Haesook T., Paul, Nicole E., Murase, Kazuyuki, Whangbo, Jennifer, Alho, Ana C., Nikiforow, Sarah, Cutler, Corey, Ho, Vincent T., Armand, Philippe, Alyea, Edwin P., Antin, Joseph H., Blazar, Bruce R., Lacerda, Joao F., Soiffer, Robert J., Ritz, Jerome
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5085610/
https://ncbi.nlm.nih.gov/pubmed/27812545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.89278
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