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Ascorbate availability affects tumor implantation-take rate and increases tumor rejection in Gulo(−/−) mice
In solid tumors, HIF1 upregulates the expression of hundreds of genes involved in cell survival, tumor growth, and adaptation to the hypoxic microenvironment. HIF1 stabilization and activity are suppressed by prolyl and asparagine hydroxylases, which require oxygen as a substrate and ascorbate as a...
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| Publicado no: | Hypoxia (Auckl) |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Dove Medical Press
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5085285/ https://ncbi.nlm.nih.gov/pubmed/27800507 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/HP.S103088 |
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