Gene and Protein Expression Is Altered by Ascorbate Availability in Murine Macrophages Cultured under Tumour-Like Conditions

Tumour-associated macrophages (TAMs) are ubiquitously present in tumours and commonly associated with poor prognosis. In immune cells, ascorbate affects epigenetic regulation, differentiation and phenotype via its co-factor activity for the 2-oxoglutarate dependent dioxygenase enzymes. Here, we dete...

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Publicado en:Antioxidants (Basel)
Autores principales: Ang, Abel D., Vissers, Margreet C. M., Burgess, Eleanor R., Currie, Margaret J., Dachs, Gabi U.
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2021
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7998289/
https://ncbi.nlm.nih.gov/pubmed/33799728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antiox10030430
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