Ascorbate modulates the hypoxic pathway by increasing intracellular activity of the HIF hydroxylases in renal cell carcinoma cells

Purpose: Protein levels and activity of the hypoxia-inducible transcription factors HIF-1 and HIF-2 are controlled by hydroxylation of the regulatory alpha chains. Proline hydroxylases (PHDs) target the protein for degradation via the von-Hippel-Lindau (VHL)-ubiquitin-ligase complex, and asparagine...

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Detalhes bibliográficos
Publicado no:Hypoxia (Auckl)
Main Authors: Wohlrab, Christina, Kuiper, Caroline, Vissers, Margreet CM, Phillips, Elisabeth, Robinson, Bridget A, Dachs, Gabi U
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2019
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6527796/
https://ncbi.nlm.nih.gov/pubmed/31192266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/HP.S201643
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