Reduction in promotor methylation utilizing EGCG (epigallocatechin-3-gallate) restores RXRα expression in human colon cancer cells

Silencing of regulatory genes through hypermethylation of CpG islands is an important mechanism in tumorigenesis. In colon cancer, RXRα, an important dimerization partner with other nuclear transcription factors, is silenced through this mechanism. We previously found that colon tumors in Apc(Min/+)...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Morris, Jay, Moseley, Vondina R., Cabang, April B., Coleman, Katie, Wei, Wei, Garrett-Mayer, Elizabeth, Wargovich, Michael J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5085231/
https://ncbi.nlm.nih.gov/pubmed/27167203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9204
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