Reduction in promotor methylation utilizing EGCG (epigallocatechin-3-gallate) restores RXRα expression in human colon cancer cells

Silencing of regulatory genes through hypermethylation of CpG islands is an important mechanism in tumorigenesis. In colon cancer, RXRα, an important dimerization partner with other nuclear transcription factors, is silenced through this mechanism. We previously found that colon tumors in Apc(Min/+)...

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Vydáno v:Oncotarget
Hlavní autoři: Morris, Jay, Moseley, Vondina R., Cabang, April B., Coleman, Katie, Wei, Wei, Garrett-Mayer, Elizabeth, Wargovich, Michael J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5085231/
https://ncbi.nlm.nih.gov/pubmed/27167203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9204
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