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Synonymous mutations in oncogenesis and apoptosis versus survival unveiled by network modeling

Synonymous mutations, which do not alter the encoded amino acid, have been routinely assumed to be ‘neutral’ and would have no effect on phenotype or fitness. Yet increasing observations have emerged to overturn this conventional concept. However, convicted elucidation of how synonymous mutations ex...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Li, Xiang, Chen, Yuan, Qi, Hong, Liu, Liyu, Shuai, Jianwei
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5085179/
https://ncbi.nlm.nih.gov/pubmed/27129147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8963
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