Obatoclax kills anaplastic thyroid cancer cells by inducing lysosome neutralization and necrosis

Poorly differentiated and anaplastic thyroid carcinomas are very aggressive, almost invariably lethal neoplasms for which no effective treatment exists. These tumors are intrinsically resistant to cell death, even when their driver oncogenic signaling pathways are inhibited. We have undertaken a det...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Champa, Devora, Orlacchio, Arturo, Patel, Bindi, Ranieri, Michela, Shemetov, Anton A, Verkhusha, Vladislav V, Cuervo, Ana Maria, Di Cristofano, Antonio
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5085168/
https://ncbi.nlm.nih.gov/pubmed/27144341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9121
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