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Obatoclax overcomes resistance to cell death in aggressive thyroid carcinomas by countering Bcl2a1 and Mcl1 overexpression

Poorly differentiated tumors of the thyroid gland (PDTC) are generally characterized by a poor prognosis due to their resistance to available therapeutic approaches. The relative rarity of these tumors is a major obstacle to our understanding of the molecular mechanisms leading to tumor aggressivene...

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Detalhes bibliográficos
Main Authors: Champa, Devora, Russo, Marika A., Liao, Xiao-Hui, Refetoff, Samuel, Ghossein, Ronald A., Di Cristofano, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4152557/
https://ncbi.nlm.nih.gov/pubmed/25012986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/ERC-14-0268
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