Obatoclax kills anaplastic thyroid cancer cells by inducing lysosome neutralization and necrosis

Poorly differentiated and anaplastic thyroid carcinomas are very aggressive, almost invariably lethal neoplasms for which no effective treatment exists. These tumors are intrinsically resistant to cell death, even when their driver oncogenic signaling pathways are inhibited. We have undertaken a det...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Champa, Devora, Orlacchio, Arturo, Patel, Bindi, Ranieri, Michela, Shemetov, Anton A, Verkhusha, Vladislav V, Cuervo, Ana Maria, Di Cristofano, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5085168/
https://ncbi.nlm.nih.gov/pubmed/27144341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9121
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