Somatic Mutations Modulate Autoantibodies against Galactose-Deficient IgA1 in IgA Nephropathy

Autoantibodies against galactose-deficient IgA1 drive formation of pathogenic immune complexes in IgA nephropathy. IgG autoantibodies against galactose-deficient IgA1 in patients with IgA nephropathy have a specific amino-acid sequence, Y(1)CS(3), in the complementarity-determining region 3 of the h...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Am Soc Nephrol
Auteurs principaux: Huang, Zhi Qiang, Raska, Milan, Stewart, Tyler J., Reily, Colin, King, R. Glenn, Crossman, David K., Crowley, Michael R., Hargett, Audra, Zhang, Zhixin, Suzuki, Hitoshi, Hall, Stacy, Wyatt, Robert J., Julian, Bruce A., Renfrow, Matthew B., Gharavi, Ali G., Novak, Jan
Format: Artigo
Langue:Inglês
Publié: American Society of Nephrology 2016
Sujets:
Brief Communications
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5084875/
https://ncbi.nlm.nih.gov/pubmed/26966014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2014101044
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