Somatic Mutations Modulate Autoantibodies against Galactose-Deficient IgA1 in IgA Nephropathy

Autoantibodies against galactose-deficient IgA1 drive formation of pathogenic immune complexes in IgA nephropathy. IgG autoantibodies against galactose-deficient IgA1 in patients with IgA nephropathy have a specific amino-acid sequence, Y(1)CS(3), in the complementarity-determining region 3 of the h...

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Detalles Bibliográficos
Publicado en:J Am Soc Nephrol
Main Authors: Huang, Zhi Qiang, Raska, Milan, Stewart, Tyler J., Reily, Colin, King, R. Glenn, Crossman, David K., Crowley, Michael R., Hargett, Audra, Zhang, Zhixin, Suzuki, Hitoshi, Hall, Stacy, Wyatt, Robert J., Julian, Bruce A., Renfrow, Matthew B., Gharavi, Ali G., Novak, Jan
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Nephrology 2016
Assuntos:
Brief Communications
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5084875/
https://ncbi.nlm.nih.gov/pubmed/26966014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2014101044
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