FBXW7 is involved in the acquisition of the malignant phenotype in epithelial ovarian tumors

FBXW7 is a ubiquitin ligase that mediates ubiquitylation of oncoproteins, such as c‐Myc, cyclin E, Notch and c‐Jun. FBXW7 is a known tumor‐suppressor gene, and mutations in FBXW7 have been reported in various human malignancies. In this study, we examined the sequences of the FBXW7 and p53 genes in...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Kitade, Shoko, Onoyama, Ichiro, Kobayashi, Hiroaki, Yagi, Hiroshi, Yoshida, Sachiko, Kato, Masaya, Tsunematsu, Ryosuke, Asanoma, Kazuo, Sonoda, Kenzo, Wake, Norio, Hata, Kenichiro, Nakayama, Keiichi I., Kato, Kiyoko
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5084658/
https://ncbi.nlm.nih.gov/pubmed/27486687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13026
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