Kinesin-1 controls mast cell degranulation and anaphylaxis through PI3K-dependent recruitment to the granular Slp3/Rab27b complex

Cross-linking of mast cell (MC) IgE receptors (FcεRI) triggers degranulation of secretory granules (SGs) and the release of many allergic and inflammatory mediators. Although degranulation depends crucially on microtubule dynamics, the molecular machinery that couples SGs to microtubule-dependent tr...

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Detaylı Bibliyografya
Yayımlandı:J Cell Biol
Asıl Yazarlar: Munoz, Isabelle, Danelli, Luca, Claver, Julien, Goudin, Nicolas, Kurowska, Mathieu, Madera-Salcedo, Iris Karina, Huang, Jian-Dong, Fischer, Alain, González-Espinosa, Claudia, de Saint Basile, Geneviéve, Blank, Ulrich, Ménasché, Gaël
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Rockefeller University Press 2016
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5084650/
https://ncbi.nlm.nih.gov/pubmed/27810912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201605073
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