Kinesin-1 controls mast cell degranulation and anaphylaxis through PI3K-dependent recruitment to the granular Slp3/Rab27b complex

Cross-linking of mast cell (MC) IgE receptors (FcεRI) triggers degranulation of secretory granules (SGs) and the release of many allergic and inflammatory mediators. Although degranulation depends crucially on microtubule dynamics, the molecular machinery that couples SGs to microtubule-dependent tr...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Munoz, Isabelle, Danelli, Luca, Claver, Julien, Goudin, Nicolas, Kurowska, Mathieu, Madera-Salcedo, Iris Karina, Huang, Jian-Dong, Fischer, Alain, González-Espinosa, Claudia, de Saint Basile, Geneviéve, Blank, Ulrich, Ménasché, Gaël
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5084650/
https://ncbi.nlm.nih.gov/pubmed/27810912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201605073
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