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Truncation of the cytoplasmic domain of beta3 in a variant form of Glanzmann thrombasthenia abrogates signaling through the integrin alpha(IIb)beta3 complex.

Glanzmann thrombasthenia is an inherited bleeding disorder characterized by absence or dysfunction of the platelet integrin alpha(IIb)beta3. Patient RM is a thrombasthenic variant whose platelets fail to aggregate in response to physiological agonists, despite the fact that they express abundant lev...

詳細記述

保存先:
書誌詳細
出版年:J Clin Invest
主要な著者: Wang, R, Shattil, S J, Ambruso, D R, Newman, P J
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Clinical Investigation 1997
主題:
オンライン・アクセス:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508438/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9351872/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119780
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