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Intraventricular and intracerebral delivery of anti-epileptic drugs in the kindling model

A means to avoid the pharmacokinetic problems affecting the anti-epileptic drugs may be their direct intracerebroventricular (ICV) or intracerebral delivery. This approach may achieve a greater drug concentration at the epileptogenic area while minimizing it in other brain or systemic areas, and thu...

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Publicat a:Neurotherapeutics
Autors principals: Barcia, Juan A., Gallego, José M.
Format: Artigo
Idioma:Inglês
Publicat: Springer-Verlag 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5084212/
https://ncbi.nlm.nih.gov/pubmed/19332328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nurt.2009.01.015
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