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Attenuation of kindled seizures by intranasal delivery of neuropeptide-loaded nanoparticles
Thyrotropin-releasing hormone (TRH; Protirelin), an endogenous neuropeptide, is known to have anticonvulsant effects in animal seizure models and certain intractable epileptic patients. Its duration of action, however, is limited by rapid tissue metabolism and the blood—brain barrier. Direct nose-to...
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| Publicado no: | Neurotherapeutics |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer-Verlag
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5084215/ https://ncbi.nlm.nih.gov/pubmed/19332331 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nurt.2009.02.001 |
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