Suppression of transcription factor PDX-1/IPF1/STF-1/IDX-1 causes no decrease in insulin mRNA in MIN6 cells.

The insulin gene transcription factor PDX-1/IPF1/STF-1/ IDX-1 plays a key role in directing beta cell-specific gene expressions. Recently, impairment of PDX-1 expression or activity has been observed in beta cell-derived HIT cells cultured under high glucose concentrations, and this has been suggest...

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Main Authors: Kajimoto, Y, Watada, H, Matsuoka, T a, Kaneto, H, Fujitani, Y, Miyazaki, J, Yamasaki, Y
Format: Artigo
Jezik:Inglês
Izdano: 1997
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC508370/
https://ncbi.nlm.nih.gov/pubmed/9312185
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