Leukocyte adhesion deficiency type 1 (LAD-1)/variant. A novel immunodeficiency syndrome characterized by dysfunctional beta2 integrins.

Leukocyte adhesion deficiency (LAD) is characterized by the inability of leukocytes, in particular neutrophilic granulocytes, to emigrate from the bloodstream towards sites of inflammation. Infectious foci are nonpurulent and may eventually become necrotic because of abnormal wound healing. LAD-1 is...

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Publicat a:J Clin Invest
Autors principals: Kuijpers, T W, Van Lier, R A, Hamann, D, de Boer, M, Thung, L Y, Weening, R S, Verhoeven, A J, Roos, D
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 1997
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508355/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9312170/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119697
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