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Improving the Safety of T Cell Therapies using an Inducible Caspase-9 Gene

Adoptive transfer of T cells can be an effective anti-cancer treatment. However, uncontrolled or unpredictable immediate or persistent toxicities are a source of concern. The ability to conditionally eliminate aberrant cells in vivo therefore is becoming a critical step for the successful translatio...

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Bibliographic Details
Published in:Exp Hematol
Main Authors: Zhou, Xiaoou, Brenner, Malcolm K.
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5083205/
https://ncbi.nlm.nih.gov/pubmed/27473568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2016.07.011
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