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An Inducible Caspase-9 Suicide Gene to Improve the Safety of Therapy Using Human Induced Pluripotent Stem Cells

Human induced pluripotent stem cells (hiPSC) hold promise for regenerative therapies, though there are several safety concerns including the risk of oncogenic transformation or unwanted adverse effects associated with hiPSC or their differentiated progeny. Introduction of the inducible caspase-9 (iC...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Yagyu, Shigeki, Hoyos, Valentina, Del Bufalo, Francesca, Brenner, Malcolm K
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817893/
https://ncbi.nlm.nih.gov/pubmed/26022733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.100
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