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An Inducible Caspase-9 Suicide Gene to Improve the Safety of Therapy Using Human Induced Pluripotent Stem Cells

Human induced pluripotent stem cells (hiPSC) hold promise for regenerative therapies, though there are several safety concerns including the risk of oncogenic transformation or unwanted adverse effects associated with hiPSC or their differentiated progeny. Introduction of the inducible caspase-9 (iC...

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Publicat a:Mol Ther
Autors principals: Yagyu, Shigeki, Hoyos, Valentina, Del Bufalo, Francesca, Brenner, Malcolm K
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817893/
https://ncbi.nlm.nih.gov/pubmed/26022733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.100
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