Low concentrations of nitric oxide increase oxygen affinity of sickle erythrocytes in vitro and in vivo.

The hallmark of sickle cell disease (SCD) is the polymerization of deoxygenated sickle hemoglobin (HbS). In SCD patients, one strategy to reduce red blood cell (RBC) sickling is to increase HbS oxygen affinity. Our objective was to determine if low concentrations of nitric oxide (NO) gas would augme...

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Autores principales: Head, C A, Brugnara, C, Martinez-Ruiz, R, Kacmarek, R M, Bridges, K R, Kuter, D, Bloch, K D, Zapol, W M
Formato: Artigo
Lenguaje:Inglês
Publicado: 1997
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC508295/
https://ncbi.nlm.nih.gov/pubmed/9276736
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