Low concentrations of nitric oxide increase oxygen affinity of sickle erythrocytes in vitro and in vivo.

The hallmark of sickle cell disease (SCD) is the polymerization of deoxygenated sickle hemoglobin (HbS). In SCD patients, one strategy to reduce red blood cell (RBC) sickling is to increase HbS oxygen affinity. Our objective was to determine if low concentrations of nitric oxide (NO) gas would augme...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Head, C A, Brugnara, C, Martinez-Ruiz, R, Kacmarek, R M, Bridges, K R, Kuter, D, Bloch, K D, Zapol, W M
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1997
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508295/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9276736/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119631
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