Improved Auditory Nerve Survival with Nanoengineered Supraparticles for Neurotrophin Delivery into the Deafened Cochlea

Cochlear implants electrically stimulate spiral ganglion neurons (SGNs) in order to provide speech cues to severe-profoundly deaf patients. In normal hearing cochleae the SGNs depend on endogenous neurotrophins secreted by sensory cells in the organ of Corti for survival. SGNs gradually degenerate f...

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Udgivet i:PLoS One
Main Authors: Wise, Andrew K., Tan, Justin, Wang, Yajun, Caruso, Frank, Shepherd, Robert K.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5082918/
https://ncbi.nlm.nih.gov/pubmed/27788219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164867
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