HIV-1 Tat Recruits HDM2 E3 Ligase To Target IRF-1 for Ubiquitination and Proteasomal Degradation

In addition to its ability to regulate HIV-1 promoter activation, the viral transactivator Tat also functions as a determinant of pathogenesis and disease progression by directly and indirectly modulating the host anti-HIV response, largely through the capacity of Tat to interact with and modulate t...

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Veröffentlicht in:mBio
Hauptverfasser: Remoli, Anna Lisa, Marsili, Giulia, Perrotti, Edvige, Acchioni, Chiara, Sgarbanti, Marco, Borsetti, Alessandra, Hiscott, John, Battistini, Angela
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5082900/
https://ncbi.nlm.nih.gov/pubmed/27795392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01528-16
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