Intracellular HIV-1 Tat protein represses constitutive LMP2 transcription increasing proteasome activity by interfering with the binding of IRF-1 to STAT1

The Tat protein is the transcriptional activator of HIV-1 gene expression, which is not only essential for viral replication, but also important in the complex HIV-induced pathogenesis of AIDS, as both an intracellular and an extracellular released protein. Accordingly, Tat is able to profoundly aff...

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Autori principali: Remoli, Anna L., Marsili, Giulia, Perrotti, Edvige, Gallerani, Eleonora, Ilari, Ramona, Nappi, Filomena, Cafaro, Aurelio, Ensoli, Barbara, Gavioli, Riccardo, Battistini, Angela
Natura: Artigo
Lingua:Inglês
Pubblicazione: Portland Press Ltd. 2006
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1462712/
https://ncbi.nlm.nih.gov/pubmed/16512786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20051570
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