MARCH2 regulates autophagy by promoting CFTR ubiquitination and degradation and PIK3CA-AKT-MTOR signaling

MARCH2 (membrane-associated RING-CH protein 2), an E3 ubiquitin ligase, is mainly associated with the vesicle trafficking. In the present study, for the first time, we demonstrated that MARCH2 negatively regulates autophagy. Our data indicated that overexpression of MARCH2 impaired autophagy, as evi...

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Bibliografiske detaljer
Udgivet i:Autophagy
Main Authors: Xia, Dan, Qu, Liujing, Li, Ge, Hongdu, Beiqi, Xu, Chentong, Lin, Xin, Lou, Yaxin, He, Qihua, Ma, Dalong, Chen, Yingyu
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2016
Fag:
Basic Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5082784/
https://ncbi.nlm.nih.gov/pubmed/27308891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1192752
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