MARCH2 regulates autophagy by promoting CFTR ubiquitination and degradation and PIK3CA-AKT-MTOR signaling

MARCH2 (membrane-associated RING-CH protein 2), an E3 ubiquitin ligase, is mainly associated with the vesicle trafficking. In the present study, for the first time, we demonstrated that MARCH2 negatively regulates autophagy. Our data indicated that overexpression of MARCH2 impaired autophagy, as evi...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Xia, Dan, Qu, Liujing, Li, Ge, Hongdu, Beiqi, Xu, Chentong, Lin, Xin, Lou, Yaxin, He, Qihua, Ma, Dalong, Chen, Yingyu
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
Assuntos:
Basic Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5082784/
https://ncbi.nlm.nih.gov/pubmed/27308891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1192752
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