Iron overload causes endolysosomal deficits modulated by NAADP-regulated 2-pore channels and RAB7A

Various neurodegenerative disorders are associated with increased brain iron content. Iron is known to cause oxidative stress, which concomitantly promotes cell death. Whereas endolysosomes are known to serve as intracellular iron storage organelles, the consequences of increased iron on endolysosom...

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Detalhes bibliográficos
Publicado no:Autophagy
Principais autores: Fernández, Belén, Fdez, Elena, Gómez-Suaga, Patricia, Gil, Fernando, Molina-Villalba, Isabel, Ferrer, Isidro, Patel, Sandip, Churchill, Grant C., Hilfiker, Sabine
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
Assuntos:
Basic Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5082776/
https://ncbi.nlm.nih.gov/pubmed/27383256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1190072
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