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Genomic charting of ribosomally synthesized natural product chemical space facilitates targeted mining

Microbial natural products are an evolved resource of bioactive small molecules, which form the foundation of many modern therapeutic regimes. Ribosomally synthesized and posttranslationally modified peptides (RiPPs) represent a class of natural products which have attracted extensive interest for t...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Skinnider, Michael A., Johnston, Chad W., Edgar, Robyn E., Dejong, Chris A., Merwin, Nishanth J., Rees, Philip N., Magarvey, Nathan A.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081660/
https://ncbi.nlm.nih.gov/pubmed/27698135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1609014113
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