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Genomic charting of ribosomally synthesized natural product chemical space facilitates targeted mining

Microbial natural products are an evolved resource of bioactive small molecules, which form the foundation of many modern therapeutic regimes. Ribosomally synthesized and posttranslationally modified peptides (RiPPs) represent a class of natural products which have attracted extensive interest for t...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Skinnider, Michael A., Johnston, Chad W., Edgar, Robyn E., Dejong, Chris A., Merwin, Nishanth J., Rees, Philip N., Magarvey, Nathan A.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081660/
https://ncbi.nlm.nih.gov/pubmed/27698135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1609014113
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