Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer

Metastatic castration-resistant prostate cancer (CRPC) is the primary cause of prostate cancer-specific mortality. Defining new mechanisms that can predict recurrence and drive lethal CRPC is critical. Here, we demonstrate that localized high-risk prostate cancer and metastatic CRPC, but not benign...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Stoyanova, Tanya, Riedinger, Mireille, Lin, Shu, Faltermeier, Claire M., Smith, Bryan A., Zhang, Kelvin X., Going, Catherine C., Goldstein, Andrew S., Lee, John K., Drake, Justin M., Rice, Meghan A., Hsu, En-Chi, Nowroozizadeh, Behdokht, Castor, Brandon, Orellana, Sandra Y., Blum, Steven M., Cheng, Donghui, Pienta, Kenneth J., Reiter, Robert E., Pitteri, Sharon J., Huang, Jiaoti, Witte, Owen N.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2016
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081658/
https://ncbi.nlm.nih.gov/pubmed/27694579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1614529113
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