Regulated large-scale nucleosome density patterns and precise nucleosome positioning correlate with V(D)J recombination

We show that the physical distribution of nucleosomes at antigen receptor loci is subject to regulated cell type-specific and lineage-specific positioning and correlates with the accessibility of these gene segments to recombination. At the Ig heavy chain locus (IgH), a nucleosome in pro-B cells is...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Pulivarthy, Sandhya R., Lion, Mattia, Kuzu, Guray, Matthews, Adam G. W., Borowsky, Mark L., Morris, John, Kingston, Robert E., Dennis, Jonathan H., Tolstorukov, Michael Y., Oettinger, Marjorie A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081657/
https://ncbi.nlm.nih.gov/pubmed/27698124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1605543113
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