Disorder drives cooperative folding in a multidomain protein

Many human proteins contain intrinsically disordered regions, and disorder in these proteins can be fundamental to their function—for example, facilitating transient but specific binding, promoting allostery, or allowing efficient posttranslational modification. SasG, a multidomain protein implicate...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Gruszka, Dominika T., Mendonça, Carolina A. T. F., Paci, Emanuele, Whelan, Fiona, Hawkhead, Judith, Potts, Jennifer R., Clarke, Jane
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2016
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081646/
https://ncbi.nlm.nih.gov/pubmed/27698144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1608762113
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