A competing hydrophobic tug on L596 to the membrane core unlatches S4–S5 linker elbow from TRP helix and allows TRPV4 channel to open

We have some generalized physical understanding of how ion channels interact with surrounding lipids but few detailed descriptions on how interactions of particular amino acids with contacting lipids may regulate gating. Here we discovered a structure-specific interaction between an amino acid and i...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Teng, Jinfeng, Loukin, Stephen H., Anishkin, Andriy, Kung, Ching
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081603/
https://ncbi.nlm.nih.gov/pubmed/27698146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1613523113
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