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L596–W733 bond between the start of the S4–S5 linker and the TRP box stabilizes the closed state of TRPV4 channel

Unlike other cation channels, each subunit of most transient receptor potential (TRP) channels has an additional TRP-domain helix with an invariant tryptophan immediately trailing the gate-bearing S6. Recent cryo-electron microscopy of TRP vanilloid subfamily, member 1 structures revealed that this...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Teng, Jinfeng, Loukin, Stephen H., Anishkin, Andriy, Kung, Ching
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371962/
https://ncbi.nlm.nih.gov/pubmed/25737550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1502366112
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