ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex

The histone methyltransferase SETDB1 plays a central role in repressive chromatin processes, but the functional requirement for its binding partner ATF7IP has remained enigmatic. Here, we show that ATF7IP is essential for SETDB1 stability: nuclear SETDB1 protein is degraded by the proteasome upon ab...

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Опубликовано в: :Cell Rep
Главные авторы: Timms, Richard T., Tchasovnikarova, Iva A., Antrobus, Robin, Dougan, Gordon, Lehner, Paul J.
Формат: Artigo
Язык:Inglês
Опубликовано: Cell Press 2016
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Report
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081395/
https://ncbi.nlm.nih.gov/pubmed/27732843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.09.050
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