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15-Deoxy-Δ(12,14)-Prostaglandin J(2) Modifies Components of the Proteasome and Inhibits Inflammatory Responses in Human Endothelial Cells
15-Deoxy-Δ(12,14)-prostaglandin J(2) (15d-PGJ(2)) is an electrophilic lipid mediator derived from PGD(2) with potent anti-inflammatory effects. These are likely to be due to the covalent modification of cellular proteins, via a reactive α,β-unsaturated carbonyl group in its cyclopentenone ring. This...
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| 出版年: | Front Immunol |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Frontiers Media S.A.
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5081389/ https://ncbi.nlm.nih.gov/pubmed/27833612 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00459 |
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