Fatty acid analogue N-arachidonoyl taurine restores function of I(Ks) channels with diverse long QT mutations

About 300 loss-of-function mutations in the I(Ks) channel have been identified in patients with Long QT syndrome and cardiac arrhythmia. How specific mutations cause arrhythmia is largely unknown and there are no approved I(Ks) channel activators for treatment of these arrhythmias. We find that seve...

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Bibliographic Details
Published in:eLife
Main Authors: Liin, Sara I, Larsson, Johan E, Barro-Soria, Rene, Bentzen, Bo Hjorth, Larsson, H Peter
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2016
Subjects:
Biophysics and Structural Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081249/
https://ncbi.nlm.nih.gov/pubmed/27690226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.20272
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