Polyunsaturated fatty acid analogs act antiarrhythmically on the cardiac I(Ks) channel

Polyunsaturated fatty acids (PUFAs) affect cardiac excitability. Kv7.1 and the β-subunit KCNE1 form the cardiac I(Ks) channel that is central for cardiac repolarization. In this study, we explore the prospects of PUFAs as I(Ks) channel modulators. We report that PUFAs open Kv7.1 via an electrostatic...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Liin, Sara I., Silverå Ejneby, Malin, Barro-Soria, Rene, Skarsfeldt, Mark Alexander, Larsson, Johan E., Starck Härlin, Frida, Parkkari, Teija, Bentzen, Bo Hjorth, Schmitt, Nicole, Larsson, H. Peter, Elinder, Fredrik
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2015
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4426425/
https://ncbi.nlm.nih.gov/pubmed/25901329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1503488112
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