Polyunsaturated fatty acid analogs act antiarrhythmically on the cardiac I(Ks) channel

Polyunsaturated fatty acids (PUFAs) affect cardiac excitability. Kv7.1 and the β-subunit KCNE1 form the cardiac I(Ks) channel that is central for cardiac repolarization. In this study, we explore the prospects of PUFAs as I(Ks) channel modulators. We report that PUFAs open Kv7.1 via an electrostatic...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Liin, Sara I., Silverå Ejneby, Malin, Barro-Soria, Rene, Skarsfeldt, Mark Alexander, Larsson, Johan E., Starck Härlin, Frida, Parkkari, Teija, Bentzen, Bo Hjorth, Schmitt, Nicole, Larsson, H. Peter, Elinder, Fredrik
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4426425/
https://ncbi.nlm.nih.gov/pubmed/25901329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1503488112
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