p62/SQSTM1 by binding to vitamin D receptor inhibits hepatic stellate cell activity, fibrosis and liver cancer

Hepatic stellate cells (HSC) play critical roles in liver fibrosis and hepatocellular carcinoma (HCC). Vitamin D receptor (VDR) activation in HSC inhibits liver inflammation and fibrosis. We found that p62/SQSTM1, a protein upregulated in liver parenchymal cells but downregulated in HCC-associated H...

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Vydáno v:Cancer Cell
Hlavní autoři: Duran, Angeles, Hernandez, Eloy D., Reina-Campos, Miguel, Castilla, Elias A., Subramaniam, Shankar, Raghunandan, Sindhu, Roberts, Lewis R., Kisseleva, Tatiana, Karin, Michael, Diaz-Meco, Maria T., Moscat, Jorge
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081228/
https://ncbi.nlm.nih.gov/pubmed/27728806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.09.004
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