Adipocyte p62/SQSTM1 suppresses tumorigenesis through opposite regulations of metabolism in adipose tissue and tumor

Obesity is a leading risk factor for cancer. However, understanding the cross-talk between adipocytes and tumor cells in vivo, independently of dietary contributions, is a major gap in the field. Here we used a prostate cancer (PCa) mouse model in which the signaling adaptor p62/Sqstm1 is selectivel...

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Veröffentlicht in:Cancer Cell
Hauptverfasser: Huang, Jianfeng, Duran, Angeles, Reina-Campos, Miguel, Valencia, Tania, Castilla, Elias A., Müller, Timo D., Tschöp, Matthias H., Moscat, Jorge, Diaz-Meco, Maria T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5896786/
https://ncbi.nlm.nih.gov/pubmed/29634950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.03.001
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